GLP-1: The very popular and proven Treatment to Help You Slim Down Quickly, safely and Easily! Take a Look!

It’s no secret that people have been looking for a shortcut that actually delivers results when it comes to weight loss. The diet industry for years has jumped from fad diet to fad diet with little success. That is why it is so exciting to see this new class of GLP-1 weight loss drugs hit the market and produce such amazing results for people across the board

The first GLP-1 analog drug was approved in 2005 and available in the market for the use is type 2 diabetes.

Unfortunately for pharmaceutical companies, it still isn’t clear whether these earlier more primitive drugs actually helped people with type 2 diabetes, so they have remained a second-line agent, after older, less expensive generic versions.

Fortunately for pharmaceutical companies, the GLP-1 analogs were found to have one beneficial side effect that isn’t seen in the earlier, older versions…

GLP-1’s Cause People to Lose Weight!

Naturally, this has led to the suggestion that they could be used as weight loss drugs in people who are obese but who don’t have diabetes. This leads us to a study that was recently published in the New England Journal of Medicine.

This was a double-blind randomized controlled trial carried out at over a hundred different sites in 16 different countries. 1,961 participants were recruited and randomized to either a the newer more modern GLP-1 analog called or a placebo.

The Study.

In order to be included in the study, participants had to be over 18 years old and they had to either have a BMI (Body Mass Index) over 30 (the cut-off for obesity), or over 27 and also have some weight-related co-morbidity (e.g. high blood pressure, high cholesterol levels, sleep apnea, or heart disease). People with diabetes were excluded since earlier studies have already shown that GLP-1 analogs are effective at reducing weight in people with type 2 diabetes. People who had previously suffered from pancreatitis (inflammation of the pancreas) were also excluded, since GLP-1 analogues have previously been shown to increase the risk of pancreatitis. The study also excluded people who had recently been taking some other form of weight loss drug, or who had had weight loss surgery.

Participants received a once-weekly injection of either the newer GLP-1 drug or a placebo. All participants also received traditional weight loss counseling once every four weeks, in which they were recommended to follow a low-calorie/low-fat diet and take regular exercise. They were followed for 68 weeks. The reason 68 weeks was chosen as the length of the study was that there was a 16-week run-in period, during which the dose of newer GLP-1 drug was gradually titrated up, followed by 52 weeks with the full dose (or a lower dose if a participant was not able to tolerate the full dose).

This is considered to be a high-quality study, with lots of participants, which provides a high level of statistical power. Usually, studies aim for a power of 80%, which means they have an 80% chance of finding a real difference if one exists. This study had a power of 99%! They recruited participants at lots of different sites in several different countries, which minimizes the risk that some condition specific to one setting will confuse the results. The intervention received by the two groups was identical, with the one exception of getting either the newer GLP-1 drug or a placebo. The participants were followed for over a year.

The average age of the participants was 46 years. The average BMI at the start of the trial was 38, and the average weight was 105 kilograms (231 pounds)

The Results!

At the end of the study, participants in newer GLP-1 drug arm had lost 14.9% of their body weight. In the placebo arm, participants had lost 2,4% of their body weight. That means an average weight loss of 15.3 kilograms (34 pounds) in the treatment group and 2,6 kilograms (5,7 pounds) in the placebo group. The absolute difference in weight loss between the two groups was 12.4%. That is a big, impressive difference. On average, participants in the treatment arm lost 13 kilograms (28 pounds) more than people in the placebo arm.

Overall, 69% of participants in newer GLP-1 drug group lost at least 10% of their body weight, compared with only 12% of participants in the placebo group. Participants in newer GLP-1 drug group also saw a much bigger reduction in their waist circumference, losing 13.5 cm, as compared with only 4.1 cm in the placebo group.

9.8% of participants in newer GLP-1 drug arm suffered an adverse event mainly consisting of gastrointestinal disorders, as compared with 6,4% in the placebo group. That gives an absolute difference of 3.4%, which would mean that roughly one in thirty people taking the drug for a year can expect to suffer an adverse event. There were no serious adverse events listed. In order to be classified as “serious”, an adverse event generally has to either result in death or at least be potentially life-threatening, or result in hospitalization, or result in permanent disability.

Conclusion:

In current studies, GLP-1s have proven highly effective at helping people to lose weight.

Prior to the FDA approval for weight loss, an earlier FDA-approved drug for weight loss in one study resulted in 2-3 kilograms of weight loss over the course of a year.

The GLP-1 class medications are offered here at Vitality Health SFL. Based on what we have seen over the last 48 months these newer GLP-1’s appear to perform at a much higher rate than the earlier GLP-1 medications, resulting in a much higher success rate of weight loss! Many of the patients we have describe this program as “Life changing”.

Please feel free to read our actual patient testimonial reviews here: Google link

Ready to Start Your Very Own Weight Loss Journey?

Visit www.vitalityhealthsfl.com to learn more about the practice and the services we offer at Vitality Health SFL in Naples, Fort Myers, Estero, Bonita Beach, Miami, Boca Raton, Hollywood, Fort Lauderdale, Winter Haven, Lakeland, Clearwater, Bradenton, Sarasota, St. Petersburg, Tampa, Winter Park, Cape Coral, and Orlando, Florida. Give us a call at 1-833-4LOWTEE to schedule your consultation with Dr. Zughbi!

We look forward to helping you push through that weight loss barrier and accomplishing your long-term health goals!

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FDA Disclaimer: This product is not intended to diagnose, treat, cure, or prevent any disease.